"Do you even know what CIVILIZED means, @SecPompeo?,"Mohammad Javad Zarif tweeted on Saturday.
"Is it sending drones over weddings to kill innocents? Piracy on the high seas," he added.
Zarif noted: "Maybe it’s pouring lethal weapons into a region to enable inhuman wars?"
He went on to say: "Or, is it a millennia-old nation that hasn’t attacked anyone for centuries?"
Earlier, Zarif in a message referred to US' various violations of the UN resolution and offering bribes for theft of oil and asked whether Iran remedial acts under the nuclear deal are unlawful.