According to Afghanistan's AVA news agency, the fourth batch includes medicines, food, clothing, tents, and other basic supplies needed by the victims of the earthquake.
Iran has previously sent three humanitarian aids to the people in quake-hit areas following the earthquake which hit Afghanistan's Paktika and Khost province on Wednesday.
According to the latest news, at least 2500 people were killed and more than 2000 others were wounded in the 6.1 magnitude earthquake quake that struck the eastern provinces of Khost and Paktika.
The quake struck about 44 km (27 miles) from the city of Khost in southeastern Afghanistan and was at a depth of 51km (31 miles).