Afkham's remarks came after the US State Department in its annual global terrorism report released on Wednesday claimed that Iran "tried to smuggle weapons to separatists in Yemen and Bahrain last year".
"Accusing Iran of supporting terrorism is distortion of facts," Afkham told reporters on Thursday.
She noted that the report has addressed the issue of terrorism “completely based on double standards and in a politically-motivated manner".
"Given documented and irrefutable evidence, Iran has been the biggest victim of terrorism in the past three decades,” Afkham said.
She noted that leveling accusation of supporting terrorism support Iran is distortion of truth.
Last month, Iranian President Hassan Rouhani underlined Tehran's rigid stance against the evil phenomena of extremism and terrorism.
"The Islamic Republic of Iran pursues a resolute, principled and unchangeable stance in its fight against terrorism and violence," President Rouhani said.
On December 18, the UN General Assembly overwhelmingly voted to approve Rouhani’s WAVE proposal, which calls on all nations across the globe to denounce violence and extremism. The Iranian president had made the proposal in his address to the UN Disarmament Conference in New York on September 25, 2013.
Under the UN resolution adopted in accordance with the WAVE proposal, the General Assembly would urge member states to take “appropriate measures to strengthen universal peace and to achieve international cooperation in solving international problems of an economic, social, cultural, or humanitarian character”.
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